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The airway smooth muscle and the pipe dream of better bronchodilators.
Can J Physiol Pharmacol
January 2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) - Université Laval, Québec, QC, Canada.
Research on airway smooth muscle has traditionally focused on its putative detrimental role in asthma, emphasizing on how its shortening narrows the airway lumen, without much consideration about its potential role in subserving the function of the entire respiratory system. New experimental evidence on mice suggests that not only the smooth muscle is required to sustain life postnatally, but its stiffening effect on the lung tissue also protects against excessive airway narrowing and, most importantly, against small airway narrowing heterogeneity and closure. These results suggest that the smooth muscle plays an vital role in the lung periphery, essentially safeguarding alveolar ventilation by preventing small airway closure.
View Article and Find Full Text PDFPipe dream: Remyelination therapy for multiple sclerosis.
Proc Natl Acad Sci U S A
August 2024
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Adoption of residential rooftop solar PV systems in South Africa: A scoping review of barriers.
Heliyon
May 2024
Department of Environmental Science, Rhodes University, P. O. Box 94, Makhanda, 6140, South Africa.
Global sustainability challenges such as climate change are linked to carbon emissions from fossil fuel powered energy needed for commercial and household consumption. South Africa is highly depended on coal for energy production hence the transition to renewable energy sources such as solar PV is seen as a pathway towards emissions reduction and a sustainable future. Yet, despite the huge potential for solar PV technologies adoption remains very low.
View Article and Find Full Text PDFGiving weight to incretin-based pharmacotherapy for obesity-related sleep apnea: a revolution or a pipe dream?
Sleep
October 2023
CIRUS Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW, Australia.
Obesity is a chronic disease affecting over 670 million adults globally, with multiple complications including obstructive sleep apnea (OSA). Substantial weight loss in patients with obesity-related OSA can reduce or even eliminate OSA as well as reduce sleepiness and improve cardio-metabolic health. Evidence suggests that these improvements exceed those that occur with device-based OSA therapies like continuous positive airway pressure which continue to be the first-line of therapy.
View Article and Find Full Text PDFPharmacotherapy for obstructive sleep apnea: Reality or Pipe Dream?
Sleep Med Rev
August 2023
Department of Otorhinolaryngology-Head and Neck Surgery, Singapore General Hospital, Singapore; Singhealth Duke-NUS Sleep Centre, Singapore; National University of Singapore, Yong Loo Lin School of Medicine and Duke-NUS Medical School Structured, Singapore. Electronic address:
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