Introduction: Carbon monoxide (CO) intoxication is one of the most common types of poisoning in the modern world. The aim of the present study is to describe the evolution of CO poisoning during a period between January 1999 and December 2007 based on data collected from result of toxicological analysis in the laboratory of toxicology in the National Institute of Health in Morocco.
Materials And Methods: This study was based on autopsies samples sent to the laboratory of forensic toxicology covering the time period January 1999 to December 2007. Cases were analyzed according to the following criteria: age, region, month, gender, presence or not of autopsy report and post mortem blood carbon monoxide determination.
Result: From January 1999 to December 2007, 139 out of the 4402 analysis performed were recorded as acute CO intoxications. Cases (93.5%) were classified as accident (E859). Hundred percentage of our cases were exclusively due to gaze inhalation. Circumstances of intoxications were described in autopsy report which is found in 41% (57 cases). Males predominated in accidental poisoning with 77 cases (55%) while females represented 62 cases (44%). the most represented city was Rabat with 48 cases (34%), followed by Casablanca with 20 cases (14.4%). the highest frequency of CO deaths was found in February and March with 29 cases (20.9%) and 28 cases (20.1%), respectively. The highest poisoning frequency was recorded for the age mean 34+/- years old. The average of carbon monoxide concentration was 5.76+/-4.3 ml/100ml of blood. Males predominated in accidental poisoning with 77 cases (55%) while females represented 62 cases (44%).
Conclusion: Acute carbon monoxide intoxication is too dangerous because of its speed in addition to the particularities of carbon monoxide which is one of many ubiquitous contaminants of our environment that requires prevention and control measures inside and outside to insure adequate protection of public health.
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http://dx.doi.org/10.1016/j.jflm.2009.01.017 | DOI Listing |
Regen Biomater
December 2024
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.
During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and the inflammatory process is accompanied by oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing and antiproliferative properties. In this study, hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle-containing coating on stainless steel was prepared for CO loading and inflammation modulation.
View Article and Find Full Text PDFScience
January 2025
Redox and Metalloprotein Research Group, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO) is fixed in a multistep process that ends with acetyl-coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In this work, we present structural snapshots of the CODH/ACS from the gas-converting acetogen , characterizing the molecular choreography of the overall reaction, including electron transfer to the CODH for CO reduction, methyl transfer from the corrinoid iron-sulfur protein (CoFeSP) partner to the ACS active site, and acetyl-CoA production. Unlike CODH, the multidomain ACS undergoes large conformational changes to form an internal connection to the CODH active site, accommodate the CoFeSP for methyl transfer, and protect the reaction intermediates.
View Article and Find Full Text PDFNicotine Tob Res
January 2025
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN.
Introduction: Hormonal contraceptives (HCs), which contain synthetic forms of estrogen (i.e., ethinyl estradiol) and/or progesterone (i.
View Article and Find Full Text PDFClin Radiol
January 2025
Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, 100029, China. Electronic address:
Aim: To evaluate the correlation between semi-quantitative analyses and visual scores of pulmonary perfusion Single Photon Emission Computed Tomography (SPECT)/ Computed Tomography (CT) imaging and pulmonary function test parameters (PFTs) in patients with interstitial lung diseases (ILDs).
Materials And Methods: This retrospective study included 35 patients with ILDs from China-Japan Friendship Hospital between January 2020 and December 2022. All patients underwent pulmonary perfusion SPECT/CT imaging and a pulmonary function test.
Nat Chem Biol
January 2025
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Diverse bacteria and archaea use atmospheric CO as an energy source for long-term survival. Bacteria use [MoCu]-CO dehydrogenases (Mo-CODH) to convert atmospheric CO to carbon dioxide, transferring the obtained electrons to the aerobic respiratory chain. However, it is unknown how these enzymes oxidize CO at low concentrations and interact with the respiratory chain.
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