The leading role of allergic components was established in some rare patterns of prostatitis. To develop the methods applicable for differential diagnosis of allergic prostatitis, the authors followed up 60 patients aged from 15 to 53 years who suffered from chronic prostatitis and 10 normal controls. The patients with bacterial disease, abacterial prostatitis with concurrent allergic components or subjects with allergic prostatitis were enrolled in the study. Immunoassay was an essential part in the diagnosis of allergic prostatitis. The study revealed a dramatic inhibition of ejaculate gamma-glutamine transferase in those who suffered from an abacterial pattern with allergic component and almost three-fold in those with allergic prostatitis. Certain though insignificant decrease in the ejaculate gamma-glutamine transferase was documented in patients with bacterial prostatitis. Investigations of ejaculate IgE revealed quite an opposite picture: 10-fold increase in IgE levels in the ejaculate of patients with allergic prostatitis as compared with other groups, controls in their number. Besides, patients with allergic prostatitis had three-fold higher IgE in the ejaculate than in the blood serum. The aforementioned phenomenon failed to be observed in patients with other patterns of prostatitis. Decreased ejaculate gamma-glutamine transferase and increased IgE can be regarded as criteria for differential diagnosis of allergic prostatitis.
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World Allergy Organ J
January 2025
Institute of Life Science, Chongqing Medical University, Chongqing, China.
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear.
Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes.
Cureus
November 2024
Cardiology, University of Arizona College of Medicine, Phoenix, USA.
Sulfamethoxazole/trimethoprim (SMX/TMP) is a commonly used antimicrobial agent for treating common bacterial infections such as urinary tract infection (UTI), combined with doxycycline for community-acquired methicillin-resistant (MRSA), and invaluable in pneumonia (PJP), previously classified as . Of its known adverse reactions, hepatotoxicity rarely comes to mind, but indeed, it is a recognized but very rare adverse reaction that may lead to liver failure in adults and even rarer in children. We present a case of hepatotoxicity in a 43-year-old male patient on no prior medication who developed jaundice and highly elevated liver enzymes one week after the administration of Bactrim for the treatment of UTI in association with prostatism, symptoms of decreased urinary force due to obstruction of flow through the prostate gland.
View Article and Find Full Text PDFArch Pharm (Weinheim)
January 2025
Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany.
Drug-induced hypotension can be harmful and may lead to hospital admissions. The occurrence of hypotension during drug therapy is preventable through increased awareness. This scoping review aimed to provide a comprehensive overview of antihypertensive and nonantihypertensive drugs associated with hypotension in adults.
View Article and Find Full Text PDFEur Ann Allergy Clin Immunol
November 2024
Department of Experimental Medicine, Postgraduate School of Respiratory Medicine, University of Rome Tor Vergata, Rome, Italy.
The aim of this contribution was to highlight the "favorable" and "unfavorable" roles of domestic and non-domestic animals on airway sensitization processes and on the type/severity of the clinical symptoms induced by their exposure. We performed a literature research in MEDLINE for allergic manifestations and animals. Pets can be "allergy friends" through mechanisms related to hygiene hypothesis and translational aspects, the dual role of IgG4 antibodies for pets, and their promising role as healthcare service animals (dogs).
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