Background: Available data regarding posttraumatic stress disorder (PTSD) in bipolar disorder (BD) are scarce and usually from a limited sample size. The present report was carried out using the Brazilian Research Consortium for Bipolar Disorders and aimed to examine whether patients with BD and comorbid PTSD are at an increased risk for worse clinical outcomes.
Methods: A consecutive sample of bipolar I outpatients from two teaching hospitals in Brazil was recruited. Patients were assessed using the Structured Clinical Interview for DSM-IV, Young Mania Rating Scale, 17-item Hamilton Rating Scale for Depression, and quality of life instrument WHOQOL-BREF. Participants were divided into three groups: a. bipolar patients with PTSD, b. bipolar patients exposed to trauma without PTSD, and c. bipolar patients with no trauma exposure.
Results: Of the 405 patients who consented to participate, 87.7% completed the survey. All three groups were similar in terms of demographic parameters. The group with comorbid PTSD reported worse quality of life, more rapid cycling, higher rates of suicide attempts, and a lower likelihood of staying recovered.
Limitations: The cross-sectional design excludes the opportunity to examine causal relationships among trauma, PTSD, and BD.
Conclusions: The findings indicate that PTSD causes bipolar patients to have a worse outcome, as assessed by their lower likelihood to recover, elevated proportion of rapid cycling periods, increased risk of suicide attempts, and worse quality of life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2009.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comorbid Bipolar Disorder and Posttraumatic Stress Disorder: Clinical Implications and Management.
Prim Care Companion CNS Disord
December 2024
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.
View Article and Find Full Text PDFPredicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health.
Front Psychiatry
November 2024
Department of Neurology, Laboratory of Stem Cell Biology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Growing evidence suggests that chronic inflammation, resulting from intricate immune system interactions, significantly contributes to the onset of psychiatric disorders. Observational studies have identified a link between immunoglobulin G (IgG) N-glycosylation and various psychiatric conditions, but the causality of these associations remains unclear.
Methods: Genetic variants for IgG N-glycosylation traits and psychiatric disorders were obtained from published genome-wide association studies.
REM disruption and REM vagal activity predict extinction recall in trauma-exposed individuals.
Psychol Med
December 2024
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Background: Accumulating evidence suggests that rapid eye movement sleep (REM) supports the consolidation of extinction memory. REM is disrupted in posttraumatic stress disorder (PTSD), and REM abnormalities after traumatic events increase the risk of developing PTSD. Therefore, it was hypothesized that abnormal REM in trauma-exposed individuals may pave the way for PTSD by interfering with the processing of extinction memory.
View Article and Find Full Text PDFErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala.
Exp Mol Med
December 2024
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea.
Article Synopsis
- PTSD often develops after traumatic events and creates problematic fear responses.
- Research using ErbB4 knockout mice revealed that loss of ErbB4 in specific neurons led to increased fear behaviors similar to PTSD.
- The findings suggest that ErbB4 plays a crucial role in distinguishing between real threats and non-threatening stimuli, particularly in mammalian brain regions associated with fear processing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!