Introduction: This article illustrates a new treatment system combining accelerated osteogenic orthodontics and osseointegrated mini-implants for minor tooth movement in severely compromised conditions. The procedures, advantages, efficacy, and indications of this method are discussed.
Methods: Three patients who needed minor tooth movement and orthodontic mini-implant treatment were recruited to use this combined technique; 1 required molar intrusion, and 2 required molar uprighting. C-Implant (diameter, 1.8 mm; length, 8.5 mm) were placed, and, after 5 weeks of healing, decortication of bone was performed near the malpositioned teeth by using a low-speed round bur. Bleeding was controlled, and the bone graft material was placed into the decorticated area. After the flap was secured, an immediate strong orthodontic force from the C-implant was applied to the teeth to start rapid tooth movement.
Results: Only a few orthodontic attachments were necessary, and the teeth moved rapidly to a good occlusal relationship without root resorption.
Conclusions: The combination of accelerated osteogenic orthodontics and a partially osteointegrated mini-implant (C-Implant) was a safe and effective treatment choice. The C-implant's surface allows partial osseointegration, so it can resist a force moment without loosening and withstand the heavy forces associated with the accelerated osteogenic orthodontics protocol.
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http://dx.doi.org/10.1016/j.ajodo.2007.08.025 | DOI Listing |
Adv Sci (Weinh)
January 2025
Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
Repairing large bone defects remains a significant clinical challenge. Stem cell is of great importance in bone regeneration, and periosteum is rich in periosteal stem cell, which has a great influence on repairing bone defects. Bioengineered periosteum with excellent biocompatibility and stem cell homing capabilities to promote bone regeneration is of great clinical significance.
View Article and Find Full Text PDFDelayed fracture healing (DFH), a common complication of post-fracture surgery, exhibits an incompletely understood pathogenesis. The present study endeavors to investigate the roles and underlying mechanisms of miR-656-3p and Bone Morphogenetic Protein-2 (BMP-2) in DFH. It was recruited 94 patients with normal fracture healing (NFH) and 88 patients with DFH of the femoral neck.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China. Electronic address:
Osteoarthritis affects approximately 500 million individuals globally, with severe cases often leading to osteochondral defects. Biomimetic collagen-hydroxyapatite scaffolds have been investigated for the treatment of osteochondral defects. However, achieving precise mimicry of the intricate composition, gradient nanostructure, and biological function of native tissue remains a formidable challenge.
View Article and Find Full Text PDFBiomolecules
January 2025
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil.
This study evaluated the osteogenic potential of the bioactive glasses SinGlass (45S5) and SinGlass High (F18) in regenerating critical bone defects in rat calvaria. Both biomaterials promoted new bone formation around the particles, with the SinGlass High (F18) group exhibiting a higher rate of bone maturation. Histomorphological and birefringence analyses revealed better organization of the newly formed bone in the biomaterial-treated groups, and immunohistochemistry indicated the expression of osteogenic markers such as osteocalcin, immunostaining for bone morphogenetic protein 2 (BMP 2), and immunostaining for bone morphogenetic protein 4 (BMP 4).
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Vascular calcification severely disrupts cardiovascular hemodynamics, leading to high rates of morbidity and mortality. Despite their clinical impact, the development of effective treatments remains limited, underscoring an urgent need for efficient and reliable drug screening methods. Vascular smooth muscle cells (VSMCs) are known to play a central role in driving the calcification process, undergoing an osteogenic transition in response to pathological conditions.
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