Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735924 | PMC |
| http://dx.doi.org/10.1172/JCI38095 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Subabul (Leucaena leucocephala L.) is a leguminous species often referred to as the "miracle tree," it provides numerous ecosystem services and exhibits robust ecological characteristics. However, the infection caused by phytopathogenic fungi is poorly understood in Subabul.
View Article and Find Full Text PDFVirulence perspective genomic research unlocks the secrets of associated with banded sheath blight in Barnyard Millet ().
Front Plant Sci
October 2024
Department of Plant Biotechnology, University of Agricultural Sciences, Bengaluru, Karnataka, India.
Introduction: Banded sheath blight (Bsb) disease, caused by , is an emerging problem in barnyard millet cultivation. One of the significant goals of pathogenomic research is to identify genes responsible for pathogenicity in the fungus.
Methods: A virulence profiling-based approach was employed and six isolates were collected from various ecological zones of India.
Multigeographic clinical assessment of a molecular diagnostic assay for detection of key codons to predict decreased susceptibility or resistance to cephalosporins in .
Antimicrob Agents Chemother
December 2024
NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Article Synopsis
- The study investigates the effectiveness of the Six-Codon assay for detecting cephalosporin resistance, crucial for improving WHO-recommended treatments.
- A thorough evaluation involved 397 known sequence isolates and 773 confirmed isolates across multiple locations, demonstrating high sensitivity (86.84%) and specificity (99.59%) for predicting antimicrobial resistance.
- The results suggest that the Six-Codon assay can be effectively used on clinical samples, offering adaptable strategies for resistance prediction and aiding in population health management.
Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation.
Development
September 2024
Institute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.
The lymphatic system is formed during embryonic development by the commitment of specialized lymphatic endothelial cells (LECs) and their subsequent assembly in primary lymphatic vessels. Although lymphatic cells are in continuous contact with mesenchymal cells during development and in adult tissues, the role of mesenchymal cells in lymphatic vasculature development remains poorly characterized. Here, we show that a subpopulation of mesenchymal cells expressing the transcription factor Osr1 are in close association with migrating LECs and established lymphatic vessels in mice.
View Article and Find Full Text PDFMarine sponge microbe provides insights into evolution and virulence of the tubercle bacillus.
PLoS Pathog
August 2024
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that have led to the tubercle bacillus becoming such a formidable human pathogen. Here we report the discovery and detailed characterization of an exceedingly slow growing mycobacterium that is closely related to M. tuberculosis for which we have proposed the species name Mycobacterium spongiae sp.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!