The distribution of aztreonam was measured in patients undergoing elective cholecystectomy. In 14 patients 2 g aztreonam was injected preoperatively and the concentration of the antibiotic was assessed in the bile from the gall bladder and common bile duct, subcutaneous tissues and serum. Samples from bile and any wound discharge were cultured and sensitivities determined. The antibiotic reached bactericidal levels in the common bile duct within 30 min of injection and such levels were maintained in skin and gall bladder for at least 4 h after injection. Aztreonam was highly effective against the Gram-negative organisms that were cultured in bile but was less effective against Enterococcus faecalis.
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