The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783704 | PMC |
| http://dx.doi.org/10.1021/cc9000949 | DOI Listing |
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