AI Article Synopsis

  • This study investigates the molecular differences in breast cancer among the Saudi population compared to Caucasians using gene expression profiling and qRT-PCR to identify subtype variations.
  • A significant discrepancy of 39% in subtype predictions was found between gene expression results and immunohistochemical profiles, with most differences seen in the luminal subtype.
  • The study highlighted a notably high frequency (28%) of HER2+ subtype and found that triple-negative tumors comprised 39% of cases, indicating a need for further research on a larger patient cohort to understand the molecular taxonomy of breast cancer in Saudis.

Article Abstract

Increasing evidence suggests the possibility of relevant molecular differences between cancers from different ethnic groups. This study uses gene expression profiling by quantitative real time polymerase chain reaction (qRT-PCR) to identify "intrinsic" subtypes in a Saudi population of breast cancers and compares the distribution of subtypes to the more commonly profiled Caucasian population. In addition, the immunohistochemical profile of breast cancers was correlated to the gene expression analysis. Discrepancy rate of 39% in subtype prediction between gene expression and immunohistochemical profile of the tumors was noticed. Most of this variation was in the luminal subtype. Frequency of HER2+ subtype in the Saudi cases was high (28%) by both the immunohistochemistry (IHC) and the qRT-PCR classification. Triple-negative tumors comprised 39% while only 11% showed a basal-like profile. Analysis of larger cohort of patients is needed to determine the molecular taxonomy of breast cancer in the Saudi population and the benefits from the diagnostic classification developed in the West.

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Source
http://dx.doi.org/10.1080/01913120903183135DOI Listing

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