Using nonevidence-based approaches to treat patients with alzheimer's disease.

Psychiatry (Edgmont)

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Published: March 2009

In this article, the author discusses the rationale behind offering patients with Alzheimer's disease treatments that are not strongly evidence based. The author will discuss specific nonevidence-based (or not strongly evidence-based) interventions psychiatrists may consider offering their patients with AD, including nonpharmacological and pharmacological approaches. The author will also discuss positive and negative aspects of these interventions and suggest some steps psychiatrists can take to try to avoid the potential downsides.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719455PMC

Publication Analysis

Top Keywords

patients alzheimer's
8
alzheimer's disease
8
offering patients
8
author will
8
will discuss
8
nonevidence-based approaches
4
approaches treat
4
treat patients
4
disease article
4
article author
4

Similar Publications

Cerebral perfusion correlates with amyloid deposition in patients with mild cognitive impairment due to Alzheimer's disease.

J Prev Alzheimers Dis

February 2025

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China, 154 Anshan Road Tianjin 300052, PR China; Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin 300052, PR China. Electronic address:

Background: Changes in cerebral blood flow (CBF) may contribute to the initial stages of the pathophysiological process in patients with Alzheimer's disease (AD). Hypoperfusion has been observed in several brain regions in patients with mild cognitive impairment (MCI). However, the clinical significance of CBF changes in the early stages of AD is currently unclear.

View Article and Find Full Text PDF

Background: α-Synuclein (α-Syn) pathology is present in 30-50 % of Alzheimer's disease (AD) patients, and its interactions with tau proteins may further exacerbate pathological changes in AD. However, the specific role of different aggregation forms of α-Syn in the progression of AD remains unclear.

Objectives: To explore the relationship between various aggregation types of CSF α-Syn and Alzheimer's disease progression.

View Article and Find Full Text PDF

Determinants of dementia diagnosis in U.S. primary care in the past decade: A scoping review.

J Prev Alzheimers Dis

February 2025

Department of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, United States.

Background: Alzheimer's disease and related dementias (ADRD) are chronically underdiagnosed in the U.S., particularly among minoritized racial and ethnic groups.

View Article and Find Full Text PDF

High definition transcranial direct current stimulation as an intervention for cognitive deficits in Alzheimer's dementia: A randomized controlled trial.

J Prev Alzheimers Dis

February 2025

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.

Background: Recent disease-modifying treatments for Alzheimer's disease show promise to slow cognitive decline, but show no efficacy towards reducing symptoms already manifested.

Objectives: To investigate the efficacy of a novel noninvasive brain stimulation technique in modulating cognitive functioning in Alzheimer's dementia (AD).

Design: Pilot, randomized, double-blind, parallel, sham-controlled study SETTING: Clinical research site at UT Southwestern Medical Center PARTICIPANTS: Twenty-five participants with clinical diagnoses of AD were enrolled from cognition specialty clinics.

View Article and Find Full Text PDF

Alzheimer's disease (AD) is the most common type of dementia and one of the leading causes of death in elderly patients. The number of patients with AD in the United States is projected to double by 2060. Thus, understanding modifiable risk factors for AD is an urgent public health priority.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!