Breast necrosis: calciphylaxis a rare cause.

Can J Plast Surg

Albany Medical Center, Albany, New York, USA.

Published: November 2011

Calciphylaxis is a small vessel vasculopathy characterized by significant calcium deposition in the vessel walls and tissue of renal failure patients. The process leads to progressive, painful, ischemic wounding. Management is generally medical; however, superinfection requires surgical intervention. A case of calciphylaxis of the breast is presented. Calciphylaxis of the breast is atypical - the wounds are usually located on the abdomen and thighs. A discussion of the process, its progression, identification and surgical management is presented. A case is made for appropriate debridement and vacuum-assisted wound therapy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691012PMC
http://dx.doi.org/10.1177/229255030801600302DOI Listing

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Article Synopsis
  • Calciphylaxis is a rare and severe condition that causes blood vessel calcification, leading to tissue death, often appearing in areas with more body fat like the abdomen and breasts.
  • An elderly woman with end-stage kidney disease experienced severe breast pain and nodules, leading to a diagnosis of calciphylaxis through clinical assessments and imaging.
  • After standard treatments failed, glucocorticoids were used effectively, showing significant improvement, but she experienced a relapse after three months, requiring treatment again.
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Aluminium in dermatology - Inside story of an innocuous metal.

Indian J Dermatol Venereol Leprol

November 2024

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.

Aluminium, the third most abundant element in the earth's crust, was long considered virtually innocuous to humans but has gained importance in the recent past. Aluminium is ubiquitous in the environment, with various sources of exposure like cosmetics, the food industry, occupational industries, the medical field, transport and electronics. Aluminium finds its utility in various aspects of dermatology as an effective haemostatic agent, anti-perspirant and astringent.

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[Not Available].

Ugeskr Laeger

January 2024

Afdeling for Plastikkirurgi og Brandsårsbehandling, Københavns Universitetshospital - Rigshospitalet.

Calciphylaxis is a rare condition characterised by painful necroses due to microvascular calcifications. It primarily affects individuals with end-stage renal disease and affected calcium-phosphate metabolism. This is a case report of a 55-year-old woman with end-stage renal disease who developed a necrotic ulcer at the breast due to calciphylaxis.

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Calciphylaxis, also called calcific uremic arteriolopathy, is a rare benign cutaneous manifestation. Although little is known about its pathogenesis, it is thought to be a result of vascular wall calcification leading to soft tissue necrosis, and it is usually encountered in patients with end-stage kidney disease (ESKD) on long-term renal dialysis. Breast calciphylaxis is a rare entity that may present as a breast mass or necrotic ulcers, and it is common for it to be initially mistaken for a malignant breast pathology.

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Introduction: Calcific uremic arteriolopathy is a life-threatening cutaneous condition in patients with chronic kidney disease. Often, clinical diagnosis is accompanied by histopathologic evaluations demonstrating vascular calcium deposits. We aimed to investigate the presence of cutaneous calcifications in non-lesional tissue in patients with chronic kidney disease, and the relation to systemic vascular calcification.

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