Calciphylaxis is a small vessel vasculopathy characterized by significant calcium deposition in the vessel walls and tissue of renal failure patients. The process leads to progressive, painful, ischemic wounding. Management is generally medical; however, superinfection requires surgical intervention. A case of calciphylaxis of the breast is presented. Calciphylaxis of the breast is atypical - the wounds are usually located on the abdomen and thighs. A discussion of the process, its progression, identification and surgical management is presented. A case is made for appropriate debridement and vacuum-assisted wound therapy.
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http://dx.doi.org/10.1177/229255030801600302 | DOI Listing |
Indian J Nephrol
September 2023
Department of Nephrology, St. John's Medical College Hospital, Bengaluru, Karnataka, India.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.
Aluminium, the third most abundant element in the earth's crust, was long considered virtually innocuous to humans but has gained importance in the recent past. Aluminium is ubiquitous in the environment, with various sources of exposure like cosmetics, the food industry, occupational industries, the medical field, transport and electronics. Aluminium finds its utility in various aspects of dermatology as an effective haemostatic agent, anti-perspirant and astringent.
View Article and Find Full Text PDFUgeskr Laeger
January 2024
Afdeling for Plastikkirurgi og Brandsårsbehandling, Københavns Universitetshospital - Rigshospitalet.
Calciphylaxis is a rare condition characterised by painful necroses due to microvascular calcifications. It primarily affects individuals with end-stage renal disease and affected calcium-phosphate metabolism. This is a case report of a 55-year-old woman with end-stage renal disease who developed a necrotic ulcer at the breast due to calciphylaxis.
View Article and Find Full Text PDFCureus
September 2023
General Surgery, Mid and South Essex NHS Foundation Trust, Basildon, GBR.
Calciphylaxis, also called calcific uremic arteriolopathy, is a rare benign cutaneous manifestation. Although little is known about its pathogenesis, it is thought to be a result of vascular wall calcification leading to soft tissue necrosis, and it is usually encountered in patients with end-stage kidney disease (ESKD) on long-term renal dialysis. Breast calciphylaxis is a rare entity that may present as a breast mass or necrotic ulcers, and it is common for it to be initially mistaken for a malignant breast pathology.
View Article and Find Full Text PDFJ Nephrol
September 2023
Department of Nephrology, Copenhagen University Hospital, Herlev, Denmark.
Introduction: Calcific uremic arteriolopathy is a life-threatening cutaneous condition in patients with chronic kidney disease. Often, clinical diagnosis is accompanied by histopathologic evaluations demonstrating vascular calcium deposits. We aimed to investigate the presence of cutaneous calcifications in non-lesional tissue in patients with chronic kidney disease, and the relation to systemic vascular calcification.
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