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Adult T-cell leukemia/lymphoma with angioimmunoblastic T-cell lymphoma-like feature and molecularly confirmed RHOA Gly 17 Val (G17V) mutation: A case report.
Pathol Int
November 2024
Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
Article Synopsis
- - An 88-year-old Japanese woman with HTLV-1 was found to have generalized lymphadenopathy and diagnosed with adult T-cell leukemia/lymphoma (ATLL) exhibiting characteristics similar to angioimmunoblastic T-cell lymphoma (AITL).
- - Biopsy results showed atypical T-cells with specific markers indicating a T-follicular helper phenotype, along with the presence of Epstein-Barr virus RNA and HTLV-1 proviral DNA, leading to the ATLL diagnosis.
- - The case highlights the complexity of diagnosing ATLL as it can mimic other T-cell lymphomas, emphasizing the importance of routine HTLV-1 screening in areas where the virus is common to prevent misdiagnosis.
Clinical spectrum of nasal involvement in cutaneous leishmaniasis.
Int J Dermatol
December 2024
Department of Medical Microbiology, Harran University Medical Faculty, Şanlıurfa, Turkey.
Article Synopsis
- The study investigates the frequency and types of cutaneous leishmaniasis (CL) lesions found in the nasal area, highlighting the potential for misdiagnosis with other inflammatory or tumoral diseases.
- Conducted retrospectively in Şanlıurfa, Turkey, between September 2022 and October 2023, it included 278 CL patients, with 34 (12.2%) showing nasal involvement, predominantly affecting males.
- The findings reveal that the majority of nasal lesions were acute, with various morphological types observed, and emphasize the importance for physicians in endemic regions to consider CL in diagnoses for nasal lesions to enable early treatment and prevent complications.
Article Synopsis
- Accurate differentiation between donor-derived post-transplant lymphoproliferative disorder (PTLD) and relapsed recipient-derived lymphoproliferative disorder (LPD) is essential for effective treatment post-hematopoietic stem cell transplantation (HSCT).
- Traditional diagnostic methods often fall short, especially in cases involving Epstein-Barr virus (EBV)-positive LPDs with low tumor cell counts.
- The newly developed method utilizes sex chromosome fluorescence in situ hybridization and other techniques on a single tissue section, successfully enabling accurate diagnosis of difficult cases and preserving histological structure.
In situ follicular neoplasm discovered as an enlarging pulmonary nodule complicated by pulmonary aspergillosis.
Thorac Cancer
May 2023
Department of Pathology, University of Yamanashi Faculty of Medicine, University of Yamanashi, Chuo Yamanashi, Japan.
In situ follicular B cell neoplasm, previously known as follicular lymphoma in situ, is a neoplastic proliferation of follicular lymphoma-like B cells confined to the germinal centers. Herein, we report a case of a woman in her 70s who initially presented with several enlarged abdominal lymph nodes. Seven months later during follow-up, a solitary pulmonary nodule was detected.
View Article and Find Full Text PDFPrimary Effusion Lymphoma-like Lymphoma Mimicking Tuberculous Pleural Effusion: Three Case Reports and a Literature Review.
Intern Med
September 2023
Department of Hematology, Okayama City Hospital, Japan.
Primary effusion lymphoma-like lymphoma (PEL-LL) is a rare lymphoma, localized in the body cavity without detectable tumor masses. Tuberculous pleural effusion is a form of extra pulmonary tuberculous. We herein report three cases of PEL-LL in patients with a history of pulmonary tuberculosis.
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