AI Article Synopsis
- The study aimed to assess how laser irradiation influences blood sugar levels and the structural and ionic properties of salivary glands in diabetic rats.
- Diabetes was induced in 120 female rats, and different laser doses were applied to their salivary glands, leading to notable improvements in blood glucose levels and reduced lipid accumulation post-irradiation.
- Findings suggest that laser irradiation may serve as a complementary treatment for managing diabetes-related complications by improving metabolic conditions in affected rats.
Article Abstract
Objectives: To evaluate the effect of laser irradiation (LI) on the glycemic state and the histological and ionic parameters of the parotid and submandibular glands in rats with diabetes.
Methods: One hundred twenty female rats were divided into eight groups. Diabetes was induced by administration of streptozotocin and confirmed later according to results of glycemia testing. Twenty-nine days after the induction, the parotid and submandibular glands of the rats were irradiated with 5, 10, and 20 J/cm2 using a laser diode (660 nm/100 mW) (without diabetes: C5, C10, and C20; with diabetes: D5, D10, and D20, respectively). On the following day, the rats were euthanized, and blood glucose determined. Histological and ionic analyses were performed.
Results: Rats with diabetes without irradiation (D0) showed lipid droplets accumulation in the parotid gland, but accumulation decreased after 5, 10, and 20 J/cm2 of laser irradiation. A decrease in fasting glycemia level from 358.97+/-56.70 to 278.33+/-87.98 mg/dL for D5 and from 409.50+/-124.41 to 231.80+/-120.18 mg/dL for D20 (p<0.05) was also observed.
Conclusion: LI should be explored as an auxiliary therapy for control of complications of diabetes because it can alter the carbohydrate and lipid metabolism of rats with diabetes.
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| http://dx.doi.org/10.1089/pho.2008.2452 | DOI Listing |
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