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Overview of Available Treatments and Their Limitations for Hypertrophic Facet Joints-A Systematic Review of the Literature.
J Am Acad Orthop Surg Glob Res Rev
January 2025
Universidad Autónoma de Guadalajara, School of Medicine, Zapopan, Mexico.
Background: Physicians worldwide face the challenging task of improving patient satisfaction by reducing pain in injured patients. Currently, available therapeutic approaches provide only short-term relief of symptoms without addressing long-term satisfaction. This has led to exploring regenerative treatment options that can deliver better outcomes.
View Article and Find Full Text PDFChimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy.
J Clin Oncol
January 2025
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Colorectal cancer (CRC) remains a major global health burden, being one of the most prevalent cancers with high mortality rates. Despite advances in conventional treatment modalities, patients with metastatic CRC often face limited options and poor outcomes. Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful in hematologic malignancies, presents a promising avenue for treating solid tumors, including CRC.
View Article and Find Full Text PDFMultifaceted barriers associated with clinical breast examination in sub-Saharan Africa: A multilevel analytical approach.
PLoS One
January 2025
Concord Clinical School, University of Sydney, Sydney, Australia.
Objectives: Clinical breast examination (CBE) open the pathway to early detection and diagnosis of breast cancer. This study examined barriers to CBE uptake in seven sub-Saharan African (SSA) countries.
Methods: Data from the most current Demographic and Health Surveys of Burkina Faso, Cote d'Ivoire, Ghana, and Kenya Mozambique, Senegal and Tanzania was used.
Risk Factors for Limb Amputations in Modern Warfare Trauma: New Perspectives.
J Am Acad Orthop Surg
January 2025
From the Israel Defense Forces, Medical Corps, Kiryat Ono (Shapira, and Epstein), the Faculty of Medicine, The Hebrew University, Jerusalem (Shapira), the Sheba Medical Center, Tel Hashomer, Ramat Gan (Shapira), the Israel National Center for Trauma and Emergency Medicine Research, Gertner Institute of Epidemiology and Health Policy Research, Sheba Medical Center, Ramat Gan (Goldman, Givon, and Katorza), the Arrow Program for Medical Research Education, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan (Katorza), the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv (Katorza, Dudkiewicz, and Prat), the Rehabilitation Division, Sheba Medical Center, Tel Hashomer, Ramat Gan (Dudkiewicz), the Critical Care Division, Rambam Health Care Campus, Haifa (Epstein), the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa (Epstein), and the Department of Orthopaedic Surgery, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel (Prat).
Background: In modern conflicts, extremities are mainly affected, with limb amputations required for approximately 5% of severely injured combatants and 7% of those with serious limb injuries. Amputations are some of the most challenging injuries endured by survivors, significantly affecting the patients and the healthcare system. This study aims to describe the rates, characteristics, and risk factors of limb amputations in patients with serious extremity trauma during the 2023 conflict in Israel.
View Article and Find Full Text PDFIntroduction: Patients undergoing hip fracture surgery face notable risks of postoperative morbidity and mortality, and racial and socioeconomic disparities in outcomes exist. This study examined the effect of social vulnerability on outcomes after hip fracture surgery using the CDC's Social Vulnerability Index (SVI).
Methods: A retrospective study of 464 patients undergoing hip fracture surgery at a single institution from July 2020 to June 2023 was conducted.
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