This article reviews the historical, instrumental, and future changes in climate for the northern latitudes of Canada. Discussion of historical climate over the last 10 000 years focuses on major climatic shifts including the Medieval Warm Period and the Little Ice Age, and how these changes compare with those most recently experienced during the period of instrumental records. In reference to the latter, details are noted about observed trends in temperature and precipitation that have been recorded over the last half century, which exhibit strong west to east and north to south spatial contrasts. A comprehensive review of future changes is also provided based on outputs from seven atmosphere-ocean global climate models and six emission scenarios. Discussion focuses on annual, seasonal, and related spatial changes for three 30-year periods centered on the 2020s, 2050s, and 2080s. In summary, substantial changes to temperature and precipitation are projected for the Canadian North during the twenty-first century. Although there is considerable variability within the various projections, all scenarios show higher temperature and, for the most part, increasing precipitation over the entire region.
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http://dx.doi.org/10.1579/0044-7447-38.5.257 | DOI Listing |
J Mol Histol
January 2025
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Tumor necrosis factor-α (TNF-α) induces a multitude of actions and consequences in bone and cartilage resorption and immune response augmentation. In this research, we aimed to investigate the effects of TNF-α on osteogenesis parameters in newborn mice. Experimental research was conducted on 42 pregnant mice, dividing into seven groups as follows: control (no injection), vehicle 1 (PBS injection on 7-9th pregnancy days (PD)), vehicle 2 (PBS injection during pregnancy), experimental 1 (injection of 10 ng/kg of TNF-α on 7-9th PD), experimental 2 (injection of 100 ng/kg of TNF-α on 7-9th PD), experimental 3 (injection of 10 ng/kg of TNF-α during pregnancy) and experimental 4 (injection of 100 ng/kg of TNF-α during pregnancy).
View Article and Find Full Text PDFJ Viral Hepat
March 2025
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea.
Alpha-fetoprotein (AFP) level and its changes in chronic hepatitis B (CHB) may influence the risk of future hepatocellular carcinoma (HCC). This study aims to evaluate the HCC risk in CHB patients with no overt HCC but with elevated AFP level and to explore the prognostic role of longitudinal changes in AFP and liver-related laboratory values. This multicentre cohort study included 10,639 CHB patients without a history of HCC from seven medical facilities in South Korea.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Coating biological membranes onto biomimetic nanocarriers improves biocompatibility, prolongs circulation, and enhances targeted delivery for cancer precision medicine. To better understand the biodistribution profiles of these biomimetic nanosystems, molecular imaging techniques, including optical imaging, radionuclide imaging, magnetic resonance imaging, and ultrasound imaging, have been widely employed for in vivo tracking and dynamic imaging. Here in this review, we delve into the profound role of these imaging modalities in visualizing changes in the tumor microenvironment, particularly in monitoring oxygen consumption and immune response dynamics, highlighting their potential to improve cancer therapies.
View Article and Find Full Text PDFTorture
January 2025
Human rights lawyer, specialized in torture and ill-treatment. Correspondence to:
This paper examines the implementation of the Global Standards on Rehabilitation (GSR) by members of the International Rehabilitation Council for Torture Victims (IRCT) and their impact on the quality of rehabilitation services provided to torture survivors. Methods: Qualitative and quantitative data were collected through surveys, post-training evaluations, and member feedback to assess the impact of the GSR on rehabilitation practices. Findings: Results show significant improvements, including more holistic rehabilitation, increased survivor participation, and stronger advocacy.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
Bennu Climate, Inc. and Symbolic Systems Program, Stanford University, Stanford, California 94305, USA.
The Linac Coherent Light Source (LCLS) is the world's first x-ray free electron laser. It is a scientific user facility operated by the SLAC National Accelerator Laboratory, at Stanford, for the U.S.
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