AI Article Synopsis
- The Na(+)-H(+) exchanger (NHE) is crucial for expelling acid in heart cells (cardiac myocytes), helping maintain pH balance.
- Experimental research has revealed the ion-dependency of NHE activity, but there are still many unanswered questions about its function.
- Developing mathematical models of NHE activity can provide insights into its role in maintaining ionic stability, particularly during disease states.
Article Abstract
Na(+)-H(+) exchanger (NHE) is the main acid extruder in cardiac myocytes. We review the experimental findings of ion-dependency of NHE activity, and the mathematical modeling developed so far. In spite of extensive investigation, many unsolved questions still remain. We consider that the precise description of NHE activity with mathematical models elucidates the roles of NHE in maintaining ionic homeostasis, especially under pathophysiological conditions.
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| http://dx.doi.org/10.1007/s10059-009-0115-y | DOI Listing |
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