Heart valve development: regulatory networks in development and disease.

Circ Res

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center ML7020, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

Published: August 2009

In recent years, significant advances have been made in the definition of regulatory pathways that control normal and abnormal cardiac valve development. Here, we review the cellular and molecular mechanisms underlying the early development of valve progenitors and establishment of normal valve structure and function. Regulatory hierarchies consisting of a variety of signaling pathways, transcription factors, and downstream structural genes are conserved during vertebrate valvulogenesis. Complex intersecting regulatory pathways are required for endocardial cushion formation, valve progenitor cell proliferation, valve cell lineage development, and establishment of extracellular matrix compartments in the stratified valve leaflets. There is increasing evidence that the regulatory mechanisms governing normal valve development also contribute to human valve pathology. In addition, congenital valve malformations are predominant among diseased valves replaced late in life. The understanding of valve developmental mechanisms has important implications in the diagnosis and management of congenital and adult valve disease.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777683PMC
http://dx.doi.org/10.1161/CIRCRESAHA.109.201566DOI Listing

Publication Analysis

Top Keywords

valve development
12
valve
11
regulatory pathways
8
normal valve
8
development
6
regulatory
5
heart valve
4
development regulatory
4
regulatory networks
4
networks development
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!