Objective: To further characterize the kinking forces and degree of curvature that result in failure of various stents, as malignant obstruction of the ureter causes failure of about half of ureteric stents.
Materials And Methods: Several stents (Silhouette 4.6 F and 6 F, Applied Medical, Rancho Santa Margarita, CA; Sof-Curl Tecoflex 6 F, Gyrus ACMI, Southborough, MA; Polaris Ultra 6 and 7 F, and Percuflex 6, 7 and 8 F stents, Boston Scientific, Natick, MA, USA) were tested. The amount of force necessary to result in kinking of the stent was measured, and the degree of curvature at failure was calculated for each stent.
Results: The Silhouette 4.6 and 6 F stents were the most resistant to failure by kinking and curvature. In general, smaller stents allowed more curvature before failing than their larger counterparts.
Conclusions: The greater allowable curvature and resistance to kinking achieved by the Silhouette ureteric stents might result in fewer stent failures in cases of malignant obstruction or other retroperitoneal processes.
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http://dx.doi.org/10.1111/j.1464-410X.2009.08833.x | DOI Listing |
Angew Chem Int Ed Engl
December 2024
Ludwig-Maximilians-Universitat Munchen, Pharmacy, Butenandtstraße 5 - 13, 81377, Munich, GERMANY.
Helical aromatic oligoamide foldamers bearing anionic side chains that mimic the overall shape and charge surface distribution of DNA were synthesized. Their interactions with chromosomal protein Sac7d, a non-sequence-selective DNA-binder that kinks DNA, were investigated by Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Circular Dichroism spectroscopy (CD), melting curve analysis, Atomic Force Microscopy (AFM), and Nuclear Magnetic Resonance (NMR), as well as by single crystal X-ray crystallography. The foldamers were shown to bind to Sac7d better than a DNA duplex of comparable length.
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December 2024
Hospital for Chronic Neurological diseases, Meidical Center Hospital Affiliated to Northwest University, Xi'an, China.
Tortuosity of the vasculature poses challenges to mechanical thrombectomy (MT); however, only a few studies have reported the impact of vertebral artery (VA) tortuosity on MT. The present study aimed to investigate the impact of tortuosity of the V1-segment VA on MT in patients with acute vertebrobasilar artery occlusion (AVBAO). The patients diagnosed with AVBAO and treated with MT in the Stroke Center of Xijing Hospital from November 2019 to March 2022 were analyzed retrospectively.
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October 2024
Institut d'Electronique Microelectronique et Nanotechnologie (IEMN CNRS UMR8520) and Département de Physique, Université de Lille, 59652, Villeneuve d'Ascq, France.
The DNA single-strand break (SSB) repair pathway is initiated by the multifunctional enzyme PARP-1, which recognizes the broken DNA ends by its two zinc-finger domains, Zn1 and Zn2. Despite a number of experiments performed with different DNA configurations and reduced fragments of PARP-1, many details of this interaction that is crucial to the correct initiation of the repair chain are still unclear. We performed Molecular Dynamics (MD) computer simulations of the interaction between the Zn1/Zn2 domains of PARP-1 and a DNA hairpin including a missing nucleotide to simulate the presence of an SSB, a construct used in recent experiments.
View Article and Find Full Text PDFNeural Regen Res
July 2025
Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
JOURNAL/nrgr/04.03/01300535-202507000-00029/figure1/v/2024-09-09T124005Z/r/image-tiff Autografting is the gold standard for surgical repair of nerve defects > 5 mm in length; however, autografting is associated with potential complications at the nerve donor site. As an alternative, nerve guidance conduits may be used.
View Article and Find Full Text PDFSaudi J Anaesth
June 2024
Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
Background: During intraoperative care, ventilatory parameters including peak inflating pressure (PIP) and exhaled tidal volumes are continuously monitored to assess changes in respiratory resistance and compliance. Changes in these parameters, such as an increase in PIP or a decrease in the exhaled tidal volume, may indicate various pathologic processes that may require immediate attention to prevent inadequate ventilation resulting in hypoxemia or hypercarbia. A kinked endotracheal tube (ETT) may mimic other pathologic processes including bronchospasm, mainstem intubation, or ventilator malfunction.
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