AI Article Synopsis

  • Urethral cancer is rare, making up less than 1% of genitourinary tumors, predominantly affecting women in their 60s and 70s, with squamous cell carcinoma being the most common type.
  • Symptoms often resemble benign conditions, leading to delays in diagnosis that can extend up to three years, resulting in most cases being diagnosed at an advanced stage with a poor prognosis.
  • Treatment approaches are not standardized due to the cancer's rarity but typically involve a combination of surgery, chemotherapy, and radiotherapy; in one case, an 80-year-old patient with advanced cancer could not undergo surgery and showed rapid disease progression despite receiving chemotherapy and radiotherapy.

Article Abstract

Urethral cancer is an infrequent pathology, less than 1% of the genitourinary tumors. It is more frequent in women (4:1), in the sixth or seventh decade of life. The most frequent histology being squamous cell carcinoma. First signs and symptoms usually are more attributable to benign stricture disease, rather than malignicy. The interval between the onset of symptoms and diagnosis may be as long as three years. Therefore most of these tumors are locally advanced at the time of diagnosis with generally poor prognosis despite aggressive treatment. Therapeutic management varies with the stage and location of the lesion. Because of the rarity of this pathology, no consensus has been reached on treatment modalities, but seems to be that must be a multimodal one, including surgery, radiotherapy and chemotherapy. We present the case of an 80 year-old male, with a diagnosis of urethral squamous-cell cancer, locally advanced at the time of diagnosis. Surgery was not feasible. The patient underwent chemotherapy and radiotherapy with evidence of quick progression thereafter.

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Source
http://dx.doi.org/10.1016/s0210-4806(09)74214-7DOI Listing

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