[Estimation of oxidation-reduction balance in subjects with metabolic syndrome together with or without periodontal diseases].

Unlabelled: Dysfunction of vascular endothelium, which lies at the bottom of atherosclerosis, mainly is caused by toxic free radicals. The aim of the study was to estimate oxidation-reduction balance in subjects with metabolic syndrome (MS).

Material And Methods: The study comprised 98 subjects (39 men and 59 women) who were divided into three groups: I group--studied: 52 subjects with MS and periodontal diseases (19 men and 33 women in mean age 48 +/- 4.2 years); II group--reference: 21 subjects with MS and without periodontal diseases (10 men and 11 women in mean age 37 +/- 4.8 years); III group--control: 25 healthy subjects and without periodontal diseases (10 men and 15 women in mean age 35 +/- 4.8 years). Metabolic syndrome was defined according to IDF criteria. To estimate oxidation-reduction balance we evaluated: TBARS concentration in red blood cells and plasma, total antioxidant status (TAS), activity of SOD-1, CAT, GSH-Px in red blood cells.

Results: In subjects with MS in comparison with control group, we observed increase of TBARS concentration in red blood cells and plasma, decrease of TAS and increase of activity of SOD-1, CAT, GSH-Px in red blood cells.

Conclusions: Periodontal diseases escalate disturbances of oxidation-reduction balance observed in subjects with metabolic syndrome. Medicaments with additive antioxidant effect can reduce disturbances of oxidation-reduction balance observed in subjects with metabolic syndrome.