Purpose: To develop practical methods at 3 Tesla (T) for measuring myocardial transverse relaxation in normal human myocardium.
Materials And Methods: Ten healthy volunteers were investigated with four multi-echo, turbo spin-echo (TSE) methods. Each method traded acquired phase encoding lines per image for echo-image sample points obtained along the T(2) decay curve. Four multi-echo turbo field-echo (TFE) methods were also tested. The TFE methods highlighted differences between achievable receiver bandwidth and echo time constraints versus the number of sample points obtained along the T(2) (*) decay curve.
Results: Measured transverse relaxation values were consistent in reported means across all scan methods. T(2) for the ventricular septum was measured as 58.8 +/- 7.7 ms (N = 10). T(2) (*) for the ventricular septum was 31.6 +/- 5.8 ms (N = 10). The variation of mean T(2) or T(2) (*) within an region of interest improved significantly with increases in acquired echoes. Therefore, four or more echoes may provide for clear distinctions between regions of altered tissue composition within a subject.
Conclusion: These results suggest that the 4-echo methods are best suited for measuring variations in transverse relaxation values in the mid-ventricular septum.
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| http://dx.doi.org/10.1002/jmri.21877 | DOI Listing |
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