AI Article Synopsis
- The research describes a chemical process where a zinc-organometallic compound is created using a specific reaction involving a beta-keto carbonyl.
- By exposing this intermediate to trimethylsilyl chloride and iodine, a product known as alpha-iodomethyl-gamma-keto carbonyl is specifically formed.
- This new iodomethyl group can be further modified to develop side chains that resemble those found in alpha-amino acids, which could have implications in various chemical or biological applications.
Article Abstract
Sequential exposure of a zinc-organometallic intermediate, generated through a zinc carbenoid-mediated chain extension reaction of a beta-keto carbonyl, to trimethylsilylchloride and iodine provided regioselective formation of an alpha-iodomethyl-gamma-keto carbonyl. The iodomethyl functionality can be further manipulated to provide side chains that are potential mimics of alpha-amino acid side chains.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598404 | PMC |
| http://dx.doi.org/10.1016/j.tet.2008.06.063 | DOI Listing |
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