Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665685 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.2774-09.2009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?
Int J Mol Sci
July 2024
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Genetic features of alcohol dependence have been extensively investigated in recent years. A large body of studies has underlined the important role of genetic variants not only in metabolic pathways but also in the neurobiology of alcohol dependence, mediated by the neuronal circuits regulating reward and craving. Serotonin transporter (5-HTT), encoded by the SLC6A4 gene (Solute carrier family 6-neurotransmitter transporter-member 4), is targeted by antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) and plays a pivotal role in serotoninergic transmission; it has been associated with psychiatric diseases and alcohol dependence.
View Article and Find Full Text PDF5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children.
PLoS One
June 2016
Research Institute of Child Development and Education, University of Amsterdam, Utrecht, The Netherlands.
Background: There is increasing evidence that variation in the promoter region of the serotonin transporter gene SLC6A4 (i.e., the 5-HTTLPR polymorphism) moderates the impact of environmental stressors on child psychopathology.
View Article and Find Full Text PDFThe 5-HTTLPR polymorphism moderates the effect of stressful life events on drinking behavior in college students of African descent.
Am J Med Genet B Neuropsychiatr Genet
July 2012
Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania and VISN4 MIRECC, Philadelphia VAMC, Philadelphia, Pennsylvania, USA.
Covault et al. [Covault et al. (2007); Biol Psychiatry 61(5): 609-616] reported that the common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene moderated the association between past-year stressful events and daily reports of drinking in a sample of European-American (EA) college students.
View Article and Find Full Text PDFInfluence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression.
J Psychiatr Res
April 2011
Department of Nuclear Medicine, University Bonn, Bonn, Germany.
Neuroimaging studies in major depressive disorder (MDD) have indicated dysregulation in a network involving prefrontal cortex, subgenual cingulate and the amygdalae, which is known to be modulated by serotonin. The serotonergic system is the principal target for pharmacological treatment in MDD and the functional variable serotonin promoter polymorphism (5-HTTLPR) influences susceptibility, course and treatment response of MDD. Using data from a previously published sample of 89 MDD-patients, we examined post hoc the effect of 5-HTTLPR status on resting state perfusion, as measured with (99m)Tc-HMPAO-SPECT.
View Article and Find Full Text PDFSerotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction.
Biol Psychol
October 2010
Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands.
In interaction with stressful life events, the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with depression. In response to stress, the hypothalamic-pituitary-adrenal (HPA) axis is activated. HPA activity is often increased in depression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!