Pyrazole NNRTIs 1: design and initial optimisation of a novel template.

Bioorg Med Chem Lett

Department of Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

Published: October 2009

The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

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http://dx.doi.org/10.1016/j.bmcl.2009.08.039DOI Listing

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