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Stereocontrolled synthesis of oxaspirobicycles via Prins-pinacol annulation. | LitMetric

We have developed the stereoselective synthesis of 2-oxaspiro[m,n]alkane derivatives using the Prins-pinacol annulation of alkene diols with a wide range of aliphatic or aromatic aldehydes and ketones. This approach was further applied for the synthesis of oxatricyclic ring system.

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http://dx.doi.org/10.1021/ol9014078DOI Listing

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