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Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle. | LitMetric

Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle.

PLoS One

Department of Cell and Tissue Biology, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, USA.

Published: August 2009

AI Article Synopsis

Article Abstract

The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-beta signaling pathway.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727005PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006741PLOS

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