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Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A?
Heliyon
December 2024
Virology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, (icddr,b), Bangladesh.
According to sparse information from various countries, the seasonal influenza virus circulation has drastically decreased during the COVID-19 pandemic. Here, we show the cross-reactivity of anti-SARS-CoV-2 antibodies against influenza viruses. Plasma samples were collected from 311 SARS-CoV-2 infected individuals.
View Article and Find Full Text PDFAntimicrobial Biphasic Polymer Coatings Enabled by Fast Diffusion of Active Compounds.
Langmuir
December 2024
General Motors Research and Development Center, Warren, Michigan 48092, United States.
The recent COVID-19 pandemic and the prospect of future global pandemics highlight the long-standing need to passively eliminate viruses and bacteria on surfaces. Conventional antimicrobial surfaces and coatings are typically constrained by a trade-off between antimicrobial efficacy and physical durability. A biphasic polyurethane coating has been developed that breaks this trade-off by incorporating a durability-imparting polycarbonate (PC) discrete phase with a continuous poly(ethylene glycol) (PEG) transport phase that absorbs, stores, and releases antimicrobial active compounds for extended microbial inactivation.
View Article and Find Full Text PDFConsortium of 'consistent amino acid substitutions' on influenza A (H1N1) viral proteins emerged at specific stages of viral infection: a big data analysis.
J Biomol Struct Dyn
December 2024
Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Hyderabad, India.
Influenza A (H1N1) virus has been one of the most common threats to humankind since 1918. The viral genome is frequently substituted, leading to new strains and recurrent pandemics. Despite knowing the effects of single amino acid substitutions on individual viral proteins, the effects of collective substitutions on viral infection remain elusive.
View Article and Find Full Text PDFInfluenza A(H5N1) shedding in air corresponds to transmissibility in mammals.
Nat Microbiol
December 2024
Department of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Article Synopsis
- An increase in spillover events of avian influenza A(H5N1) to mammals indicates that certain virus strains are adapting for better transmission among mammals.
- Research using air-sampling devices to monitor ferrets shows that earlier strains of A(H5N1) didn't effectively transmit due to low airborne virus shedding, not a lack of mutations needed for adaptation.
- In contrast, while human A(H1N1) was easily detected in the air, some A(H5N1) strains from 2005 and 2024 were not, although a couple of ferrets infected with a 2022 European polecat strain and a 2024 strain from a farm worker did shed infectious virus.
Monitoring Influenza A (H1N1, H3N2), RSV, and SARS-CoV-2 Using Wastewater-Based Epidemiology: A 2-Year Longitudinal Study in an Indian Megacity Covering Omicron and Post-Omicron Phases.
Food Environ Virol
November 2024
Biochemical Sciences Division, CSIR-National Chemical Laboratory (NCL), National Collection of Industrial Microorganisms (NCIM), Pune, 411008, Maharashtra, India.
The bourgeoning field of wastewater-based epidemiology (WBE) for the surveillance of several respiratory viruses which includes Influenza A, H1N1pdm09, H3N2, respiratory syncytial viruses (RSV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of interest for public health concerns. However, there are few long-term monitoring studies globally. In this study, respiratory viruses were detected and quantified from 11 sewer sheds by utilizing reverse transcription-quantitative polymerase chain reaction analysis in Pune city, India, from Jan 2022 to Dec 2023.
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