Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725013 | PMC |
| http://dx.doi.org/10.1073/pnas.0900162106 | DOI Listing |
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