1. Tissue perfusion was measured in seven sheep by the radioactive microsphere method. 2. The sheep were anaesthetised and ventilated to a near normal arterial carbon dioxide tension. 3. Cardiac output was measured utilizing the Fick principle as applied to thermodilution and at the end of the investigation the sheep were killed by an overdose of anaesthetic. 4. The results were compared with previously published values for conscious sheep and anaesthetised horses and found to be similar when known variations in body composition and physiology were considered.
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