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Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats.
Saudi Pharm J
December 2024
School of Biological Science, Jining Medical University, Rizhao 276826, Shandong Province, PR China.
Phenylacetylglycine (PAGly) is a small molecule derived from phenylalanine in the gut glycine degradation and conjugation. It has been associated with both the progression of atherosclerosis and protective effects on the myocardium. This study evaluated the function and the underlying mechanisms of PAGly in a rat cerebral ischemia/reperfusion (I/R) injury model.
View Article and Find Full Text PDFUnraveling the Structural Basis of Biased Agonism in the β-Adrenergic Receptor Through Molecular Dynamics Simulations.
Proteins
November 2024
Department of Biopharmacy, Medical University of Lublin, Lublin, Poland.
Biased agonism in G protein-coupled receptors is a phenomenon resulting in the selective activation of distinct intracellular signaling pathways by different agonists, which may exhibit bias toward either Gs, Gi, or arrestin-mediated pathways. This study investigates the structural basis of ligand-induced biased agonism within the context of the β-adrenergic receptor (β-AR). Atomistic molecular dynamics simulations were conducted for β-AR complexes with two stereoisomers of methoxynaphtyl fenoterol (MNFen), that is, compounds eliciting qualitatively different cellular responses.
View Article and Find Full Text PDFIntelligent spectrophotometric resolution platforms for the challenging spectra of ipratropium and fenoterol in their combination inhaler with ecological friendliness assessment.
Sci Rep
September 2024
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Al-Aini Street, Cairo, 11562, Egypt.
Article Synopsis
- Asthma and COPD are common respiratory issues, and a new combination drug of Ipratropium and Fenoterol has been developed for symptom management.
- Researchers created three innovative, cost-effective spectrophotometric methods to accurately measure these drugs together in their inhaler form, using water as a green solvent and eliminating separation steps.
- These methods involve various approaches, such as zero-order absorption and ratio spectrum techniques, successfully addressing challenges in detecting Ipratropium and proving effective across specific concentration ranges according to industry guidelines.
Chromatographic fingerprinting of ipratropium and fenoterol in their novel co-formulated inhaler treating major respiratory disorders; application to delivered dose uniformity testing along with greenness and whiteness assessment.
BMC Chem
August 2024
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Al-Aini Street, Cairo, 11562, Egypt.
Ipratropium bromide (IPR) and fenoterol hydrobromide (FEN) have recently been combined in a promising inhaler to treat two prevalent inflammatory illnesses of the airways: bronchial asthma and chronic obstructive pulmonary disease (COPD). The necessity for a single, sensitive, and trustworthy analytical approach to cover the diverse and necessary tests of in-vitro and in-vivo studies is greatly grown with the rising production of new fixed combinations. Two novel, selective and environmentally friendly LC techniques were developed in order to guarantee precise measurement of IPR and FEN in their challenging formulation.
View Article and Find Full Text PDFDiesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells.
Front Toxicol
July 2024
Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.
Air pollution from diesel combustion is linked in part to the generation of diesel exhaust particles (DEP). DEP exposure induces various processes, including inflammation and oxidative stress, which ultimately contribute to a decline in lung function. Cyclic AMP (cAMP) signaling is critical for lung homeostasis.
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