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Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching.
Sci Rep
June 2024
Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA.
Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation, vascular density, endothelial junctions, and polarization in response to flow. Notch proteins form transcriptional activation complexes that regulate endothelial gene expression, but few of the downstream effectors that enable these phenotypic changes have been characterized in endothelial cells, limiting our understanding of vascular Notch activities. Using an unbiased screen of translated mRNA rapidly regulated by Notch signaling, we identified novel in vivo targets of Notch signaling in neonatal mouse brain endothelium, including UNC5B, a member of the netrin family of angiogenic-regulatory receptors.
View Article and Find Full Text PDFDimethyl sulfoxide acutely enhances regulated insulin secretion in the MIN6-K8 mouse insulinoma cell line.
Histochem Cell Biol
July 2021
Division of Endocrinology, Diabetes, and Metabolism; Department of Medicine, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott, Suite E625, M/C 640, Chicago, IL, 60612, USA.
Diabetes mellitus is a metabolic disorder projected to afflict 700 million people globally by 2045. Fundamental to the progression of diabetes is an insufficient supply of insulin to meet metabolic demand. The MIN6-K8 cell line is a mouse insulinoma model of pancreatic β-cells frequently used to study the mechanisms of insulin secretion.
View Article and Find Full Text PDFResponse to Letter to the Editor: "Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care".
J Clin Endocrinol Metab
January 2021
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer.
Clin Cancer Res
September 2020
University of Utah, Salt Lake City, Utah.
Purpose: Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel-Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a tumor promoting role for HIF-2α, and a tumor suppressor role for HIF-1α. However, few studies have comprehensively examined the clinical relevance of this paradigm.
View Article and Find Full Text PDFThe Impact of the Affordable Care Act Medicaid Expansion on Type 2 Diabetes Diagnosis and Treatment: A National Survey of Physicians.
J Community Health
June 2019
Section of General Internal Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Ave. MC 2007, Chicago, IL, 60637, USA.
In 2014, the Affordable Care Act (ACA) provided funding for states to expand Medicaid coverage to include citizens who earned up to 138% of the federal poverty line. We sought to ascertain whether physicians practicing in Medicaid expansion states reported an increase in Medicaid or newly insured patients with type 2 diabetes in their panels, compared to physicians practicing in non-expansion states. We conducted a 55-question cross-sectional survey of 356 physicians providing outpatient care for adults with type 2 diabetes.
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