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Multicenter Normative Data for Mesopic Microperimetry.
Invest Ophthalmol Vis Sci
October 2024
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Purpose: The purpose of this study was to provide a large, multi-center normative dataset for the Macular Integrity Assessment (MAIA) microperimeter and compare the goodness-of-fit and prediction interval calibration-error for a panel of hill-of-vision models.
Methods: Microperimetry examinations of healthy eyes from five independent study groups and one previously available dataset were included (1137 tests from 531 eyes of 432 participants [223 women and 209 men]). Linear mixed models (LMMs) were fitted to the data to obtain interpretable hill-of-vision models.
Retina as a potential biomarker for the early stage of Alzheimer's disease spectrum.
Ann Clin Transl Neurol
October 2024
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Objective: To characterize the retinal microvasculature and structure in subjective cognitive decline (SCD) and identify the potential biomarker for the early stage of the Alzheimer's disease (AD) spectrum.
Methods: In this study, 35 patients with SCD, 36 with cognitive impairment, and 29 with normal cognition (NC) were enrolled. Optical coherence tomography angiography was employed to assess retinal vascular density, fovea avascular zone area, and retinal thickness.
Multimodal imaging in diabetic retinopathy and macular edema: An update about biomarkers.
Surv Ophthalmol
September 2024
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; Eye Clinic, IRCCS MultiMedica, Milan, Italy. Electronic address:
Diabetic macular edema (DME), defined as retinal thickening near, or involving the fovea caused by fluid accumulation in the retina, can lead to vision impairment and blindness in patients with diabetes. Current knowledge of retina anatomy and function and DME pathophysiology has taken great advantage of the availability of several techniques for visualizing the retina. Combining these techniques in a multimodal imaging approach to DME is recommended to improve diagnosis and to guide treatment decisions.
View Article and Find Full Text PDFOptical coherence tomography angiography as a potential tool in differential diagnosis of multiple sclerosis and rheumatic disorders with central nervous system involvement.
Int Ophthalmol
June 2024
Department of Ophthalmology, Medical University of Lodz, 90-414, Lodz, Poland.
Purpose: The aim of this study is to analyse whether optical coherence tomography angiography (angio-OCT, OCTA) measurements can be a useful tool to differentiate central nervous system (CNS) involvement in rheumatic disorders (RD) from multiple sclerosis (MS).
Methods: A total of 85 patients- 41 with MS, 21 with RD with CNS involvement and 23 healthy controls were included in the study. All individuals underwent OCTA and the following parameters were measured in each eye separately: average foveal and parafoveal vessel density (VD), average foveal and parafoveal vessel length (VL) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as area, perimeter, and circularity of the foveal avascular zone.
Retinal image registration method for myopia development.
Med Image Anal
October 2024
Nankai University Eye Institute, Nankai University, Tianjin 300350, China; Institute of Robotics and Automatic Information System (IRAIS), the Tianjin Key Laboratory of Intelligent Robotic (tjKLIR), Nankai University, Tianjin 300350, China. Electronic address:
Objective: The development of myopia is usually accompanied by changes in retinal vessels, optic disc, optic cup, fovea, and other retinal structures as well as the length of the ocular axis. And the accurate registration of retinal images is very important for the extraction and analysis of retinal structural changes. However, the registration of retinal images with myopia development faces a series of challenges, due to the unique curved surface of the retina, as well as the changes in fundus curvature caused by ocular axis elongation.
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