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Water use strategies in pines and oaks across biomes are modulated by soil water availability.
Tree Physiol
March 2025
CREAF, Bellaterra (Cerdanyola del Vallès), Catalonia, Spain.
Quercus and Pinus are amongst the most economically and ecologically relevant genera of woody species across northern hemisphere forests. Mixed pine-oak woodlands are also abundant in temperate and Mediterranean regions. The recent shift towards dominance of oaks in detriment of pines, reported in several regions, could be partly driven by differential drought responses between genera and associated with climate change.
View Article and Find Full Text PDFShank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome.
Mol Psychiatry
March 2025
CNR, Neuroscience Institute, Milano, Italy.
Mutations or deletions in the SHANK3 gene have been identified in up to 1% of autism spectrum disorder cases and are considered the primary cause of neuropsychiatric symptoms in Phelan McDermid syndrome (PMS). While synaptic dysfunctions have been extensively documented in the absence of Shank3, other mechanisms through which Shank3 may regulate neuronal functions remain unclear. In this study, we report that the ribosomal protein Rpl3 and overall protein synthesis are downregulated in the cortex and striatum of Shank3 knockout (KO) mice and in neurons differentiated from human-induced pluripotent stem cells (hiPSCs) derived from a PMS patient.
View Article and Find Full Text PDFTRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.
NPJ Microgravity
March 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, P.R. China.
Stem cell differentiation must be regulated by intricate and complex interactions between cells and their surrounding environment, ensuring normal organ and tissue morphology such as the liver. Though it is well acknowledged that microgravity provides necessary mechanical force signals for cell fate, how microgravity affects growth, differentiation, and communication is still largely unknown due to the lack of real experimental scenarios and reproducibility tools. Here, Rotating Flat Chamber (RFC) was used to simulate ground-based microgravity effects to study how microgravity effects affect the differentiation of HepaRG (hepatic progenitor cells) cells.
View Article and Find Full Text PDFAxonal RNA localization is essential for long-term memory.
Nat Commun
March 2025
Institut de Biologie Valrose, Université Côte d'Azur, CNRS, Inserm, Nice, France.
Localization of mRNAs to neuronal terminals, coupled to local translation, has emerged as a prevalent mechanism controlling the synaptic proteome. However, the physiological regulation and function of this process in the context of mature in vivo memory circuits has remained unclear. Here, we combined synaptosome RNA profiling with whole brain high-resolution imaging to uncover mRNAs with different localization patterns in the axons of Drosophila Mushroom Body memory neurons, some exhibiting regionalized, input-dependent, recruitment along axons.
View Article and Find Full Text PDFGenetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5.
Cell Death Dis
March 2025
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Traumatic brain injury (TBI) is a significant global health concern that often results in death or disability, and effective pharmacological treatments are lacking. G protein-coupled receptor 56 (GPR56), a potential drug target, is crucial for neuronal and glial cell function and therefore plays important roles in various neurological diseases. Here, we investigated the potential role and mechanism of GPR56 in TBI-related damage to gain new insights into the pharmacological treatment of TBI.
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