The authors report the case of an eleven-month old infant who was given maprotiline and clobazam. He was found in coma state and suffered from convulsions, that were treated with phenobarbital. The electrocardiogram showed a right bundle branch block and a left anterior hemiblock over 72 h. The child then recovered without sequelae.
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Pediatr Emerg Care
September 2014
Department of Pediatric Emergency King Khalid University Hospital King Saud University Riyadh, Saudi Arabia.
Clin Toxicol (Phila)
July 2014
Swiss Toxicological Information Centre, Associated Institute of the University of Zürich, Zürich , Switzerland.
Context: Seizures during intoxications with pharmaceuticals are a well-known complication. However, only a few studies report on drugs commonly involved and calculate the seizure potential of these drugs.
Objectives: To identify the pharmaceutical drugs most commonly associated with seizures after single-agent overdose, the seizure potential of these pharmaceuticals, the age-distribution of the cases with seizures and the ingested doses.
J Pain
April 2007
Department of Ion Channels, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA.
Unlabelled: Sodium channel blockers such as lidocaine, lamotrigine, and carbamazepine can be effective in the treatment of neuropathic pain. Though not approved for neuropathic pain indications, tricyclic antidepressants are often considered first-line treatment for conditions such as post-herpetic neuralgia and diabetic neuropathy. Several tricyclic antidepressants have been shown to block peripheral nerve sodium channels, which may contribute to their antihyperalgesic efficacy.
View Article and Find Full Text PDFNeurology
March 2003
Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. ohkoshin@ md.tsukuba.ac.jp
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