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Article Abstract
Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254787 | PMC |
| http://dx.doi.org/10.3390/molecules14082836 | DOI Listing |
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