AI Article Synopsis
- The liver is commonly affected by amyloid deposits in systemic amyloidosis, as seen in a case study of a 52-year-old woman with symptoms including liver enlargement and abnormal liver enzyme levels.
- Laboratory tests revealed proteinuria with lambda light chains, and imaging showed an enlarged liver with normal blood flow.
- Diagnosis was supported by a fat biopsy showing amyloid presence, alongside tests indicating high liver stiffness, confirming amyloid infiltration and low-grade plasmacytoma with amyloidosis without needing a liver biopsy.
Article Abstract
The liver is a common site of amyloid deposition in primary systemic amyloidosis. We report the case of a 52-year-old white woman complaining of hepatomegaly, high levels of alkaline phosphatase and serum gamma-glutamyl transferase. Other laboratory tests showed proteinuria with light-chain type lambda. Color Doppler ultrasonography showed an enlarged bright liver with hepatopetal portal blood flow. Fine-needle aspiration biopsy of abdominal fat, with Congo red stain, was positive for amyloid. No liver biopsy was performed, but transient elastography showed high liver stiffness values (75 kPa), suggestive of amyloid infiltration, as other causes of elevation had been ruled out by clinical, laboratory and radiological findings. Bone marrow morphology and immunoistochemistry confirmed low-grade plasmacytoma with amyloidosis.
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| http://dx.doi.org/10.1097/MEG.0b013e3283309d5b | DOI Listing |
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