FHIT and WWOX are tumor suppressor genes that span the common fragile sites FRA3B and FRA16D, respectively. To analyze possible synergisms among these genes in cervical cancer progression, we considered 159 cervical intraepithelial neoplasias, and 58 invasive squamous cell carcinomas of the uterine cervix. All cases were previously selected as high risk HPV. FHIT and WWOX proteins were examined by immunohistochemistry and their expression was inversely correlated with precancerous vs. invasive lesions. Statistics among biological markers indicated an association between FHIT and WWOX. Protein expression of these two genes was also absent or reduced in cancer cell lines. Thus, WWOX may be considered as a novel important genetic marker in cervical cancer and the association between the altered expression of FHIT and WWOX may be a critical event in the progression of this neoplasia.
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| http://dx.doi.org/10.1016/j.canlet.2009.07.017 | DOI Listing |
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Article Synopsis
- Fhit and Wwox protein expression is often diminished in various human cancers, leading to important consequences for DNA repair and genome stability.
- The study indicates that Fhit loss triggers mild genome instability due to replication stress in mouse kidney cells, which can be alleviated with thymidine supplementation.
- Additionally, Wwox loss correlates with poor treatment responses in breast and ovarian cancers and may occur alongside Fhit loss, suggesting a combined effect on cancer progression and potential treatment targets.
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