Background: Angiotensin-converting enzyme 2 (ACE2) is an endogenous counterregulator of the renin-angiotensin system. The relationship between soluble ACE2 (sACE2), myocardial function, and clinical outcomes in patients with chronic systolic heart failure is not well established.
Methods And Results: We measured sACE2 activity in 113 patients with chronic systolic heart failure (left ventricular ejection fraction [LVEF]
Conclusions: Elevated plasma sACE2 activity was associated with greater severity of myocardial dysfunction and was an independent predictor of adverse clinical events.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179261 | PMC |
| http://dx.doi.org/10.1016/j.cardfail.2009.01.014 | DOI Listing |
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