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Initiation of Antipsychotics During the First Year After First-Episode Psychosis: A Population-Based Study.
Acta Psychiatr Scand
November 2024
Niuvanniemi Hospital, Kuopio, Finland.
Background: Antipsychotics are recommended after first-episode psychosis. Knowledge on the current use patterns in real-world settings is thus important to inform clinical practice. We aimed to describe antipsychotic initiation during 1 year after first-episode psychosis and its associated factors.
View Article and Find Full Text PDFNon-prescribing of clozapine for outpatients with schizophrenia in real-world settings: The clinicians' perspectives.
Schizophrenia (Heidelb)
December 2023
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians have found that some of the most frequently cited barriers to clozapine prescribing are related to the blood-monitoring requirements. However, these surveys tend to explore general perspectives and may not reflect the true impact of different barriers in real-world outpatient settings.
View Article and Find Full Text PDFSchizophrenia treatment with a combination of two LAI antipsychotics: A case report.
Front Psychiatry
September 2022
Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Preventing the relapse of a psychotic episode is a challenge for the treatment of schizophrenia. Patients with schizophrenia suffer from a few to a dozen relapses in their lifetime. The use of long-acting injectable (LAI) antipsychotics in the treatment of schizophrenia is associated with less frequent recurrences of psychotic symptoms, better compliance, and better quality of life.
View Article and Find Full Text PDFA Case of Hyper Sexuality Probably Associated with Clozapine.
Psychopharmacol Bull
June 2018
Thomson, MBBS, Post graduate student, Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Karnataka, India. Patil, Associate Professor, MBBS, MD, Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Karnataka, India. Ommurugan, MBBS, Post graduate student, Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Karnataka, India. Bhandary, MBBS, Associate Professor, Department of Psychiatry, Kasturba Medical College, Manipal Campus, Manipal, India.
Introduction: Schizophrenia treatment needs to cover several psychological interventions and pharmacological treatment for stabilizing the disease course and decreasing relapses. Sexual side effects are a major hindrance to patients and lead to decreased adherence to therapy and reduced quality of life. Recently, several studies outlined that sexual dysfunction is one of the most distressing side effects of antipsychotics and a major cause of a poor quality of life.
View Article and Find Full Text PDFClozapine use in early psychosis.
Schizophr Res
September 2018
Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, Victoria 3052, Australia; Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia; Orygen Youth Health, 35 Poplar Road, Parkville, Victoria 3052, Australia. Electronic address:
Background: The superior efficacy of clozapine in treatment resistant schizophrenia has been clearly demonstrated, yet there are often delays in the commencement of clozapine. In this study, we aimed to determine; the proportion of young people with a first episode of psychosis (FEP) who would be considered eligible for clozapine treatment, the theoretical delay in commencing clozapine and to compare the outcomes of those treated with clozapine to those who were eligible but not treated with clozapine.
Methods: This study was conducted at Orygen Youth Health (OYH), a youth mental health service for young people aged 15-24.
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