AI Article Synopsis
- The systematic review aimed to evaluate interventions for depression in adults after traumatic brain injury (TBI) and make recommendations for practice and research.
- A total of 658 articles were initially identified, with 57 meeting inclusion criteria, and ultimately 27 studies were included that focused on interventions for TBI-related depression.
- The findings suggest that while serotonergic antidepressants and cognitive behavioral therapies show promise, there is a major lack of rigorous randomized controlled trials in this area, indicating a need for further research.
Article Abstract
The aim of this systematic review was to critically evaluate the evidence on interventions for depression following traumatic brain injury (TBI) and provide recommendations for clinical practice and future research. We reviewed pharmacological, other biological, psychotherapeutic, and rehabilitation interventions for depression following TBI from the following data sources: PubMed, CINAHL, PsycINFO, ProQuest, Web of Science, and Google Scholar. We included studies written in English published since 1980 investigating depression and depressive symptomatology in adults with TBI; 658 articles were identified. After reviewing the abstracts, 57 articles met the inclusion criteria. In addition to studies describing interventions designed to treat depression, we included intervention studies in which depressive symptoms were reported as a secondary outcome. At the end of a full review in which two independent reviewers extracted data, 26 articles met the final criteria that included reporting data on participants with TBI, and using validated depression diagnostic or severity measures pre- and post-treatment. Three external reviewers also examined the study methods and evidence tables, adding 1 article, for a total of 27 studies. Evidence was classified based on American Academy of Neurology criteria. The largest pharmacological study enrolled 54 patients, and none of the psychotherapeutic/rehabilitation interventions prospectively targeted depression. This systematic review documents that there is a paucity of randomized controlled trials for depression following TBI. Serotonergic antidepressants and cognitive behavioral interventions appear to have the best preliminary evidence for treating depression following TBI. More research is needed to provide evidence-based treatment recommendations for depression following TBI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864457 | PMC |
| http://dx.doi.org/10.1089/neu.2009.1091 | DOI Listing |
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