The effect of exaprolol and sodium salicylate on hemolysis of erythrocytes was studied in dependence on the age of rats. Rats of the Wistar strain were used in the experiment in six different age groups. Exaprolol concentration was in the range from 0.24 to 0.48 mmol.l-1. Sodium salicylate was used in the concentrations of 0.1, 1, and 5 mmol.l-1. The effect of sodium salicylate on exaprolol induced hemolysis depended on the concentration of the two drugs and on the age of the animals. Significant changes were recorded at the concentrations of 1 and 5 mmol.l-1 of sodium salicylate. In 48- and 72-week-old rats sodium salicylate stabilized the erythrocyte membrane, whereas in 3-week-old rats increased decomposition was observed. The differences in the membrane labilizing effect of exaprolol and the membrane stabilizing effect of sodium salicylate, which were found to be age dependent, are presumably determined by qualitative changes in the structure of the erythrocyte membrane occurring in the course of postnatal development.
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