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A plasmid with the gene enhances the fitness of strains under laboratory conditions.
Microbiology (Reading)
January 2025
Instituto de Microbiologa, Colegio de Ciencias Biolgicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador.
Antimicrobial resistance (AMR) is a major threat to global public health that continues to grow owing to selective pressure caused by the use and overuse of antimicrobial drugs. Resistance spread by plasmids is of special concern, as they can mediate a wide distribution of AMR genes, including those encoding extended-spectrum -lactamases (ESBLs). The CTX-M family of ESBLs has rapidly spread worldwide, playing a large role in the declining effectiveness of third-generation cephalosporins.
View Article and Find Full Text PDFAirway stenosis (AS) is a fibroinflammatory disease characterized by abnormal activation of fibroblasts and excessive synthesis of extracellular matrix, which has puzzled many doctors despite its relatively low prevalence. Traditional treatment such as endoscopic surgery, open surgery, and adjuvant therapy have many disadvantages and are limited in the treatment of patients with recurrent AS. Therefore, it is urgent to reveal the pathogenesis of AS and accelerate its clinical transformation.
View Article and Find Full Text PDFMemory-based predictions prime perceptual judgments across head turns in immersive, real-world scenes.
Curr Biol
January 2025
Department of Psychological and Brain Sciences, Dartmouth College, 3 Maynard Street, Hanover, NH 03755, USA. Electronic address:
Each view of our environment captures only a subset of our immersive surroundings. Yet, our visual experience feels seamless. A puzzle for human neuroscience is to determine what cognitive mechanisms enable us to overcome our limited field of view and efficiently anticipate new views as we sample our visual surroundings.
View Article and Find Full Text PDFSerpiginous-Like Choroiditis with ANCA-PR3 Vasculitis in a Patient from Endemic Country: A Complex Phenotypic, Immunological and Epidemiological Puzzle.
Ocul Immunol Inflamm
December 2024
Division of Infectious Diseases, Integrated Health Services Institute (IHI), Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Purpose: To report a complex case of serpiginous-like choroiditis (SLC) in a patient with anti-neutrophil cytoplasmic antibody (ANCA)-anti-proteinase 3 (PR3)-associated vasculitis with systemic involvement.
Methods: Case report.
Results: A 40-year-old male from a tuberculosis (TB)-endemic region presented with bilateral active SLC lesions.
Surgical Puzzle: Concurrent Comprehensive Neck Dissection Strategies Unravelling the Mystery of Carcinoma Unknown Primary when Performed with TORS Radical Tonsillectomy and Mucosal Tongue Base Wedge Biopsy in Northern Indian Cohort.
Indian J Otolaryngol Head Neck Surg
December 2024
Department of Otorhinolaryngology and Head-Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 India.
Article Synopsis
- The study focuses on patients with carcinoma of unknown primary who underwent specific surgical procedures, including transoral robotic surgery and neck dissection, to understand the patterns of cervical nodal metastasis.
- It reports a majority of patients presenting clinically as N2b, while histopathological results showed a higher prevalence of N3b disease, indicating some discrepancy between clinical evaluation and actual disease state.
- The most affected lymph node level was consistently found to be level II, with significant findings related to Lymph Node Yield (LNY) and emerging concepts like Lymph Node Ratio (LNR) and Lymph Node Density (LND) to better analyze the metastasis characteristics.
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