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Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury.
Intensive Care Med Exp
December 2023
Charité - Universitätsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Berlin, Germany.
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients. Phrenic nerve stimulation (PNS) has been a valuable tool for diagnosing VIDD by assessing respiratory muscle strength in response to magnetic PNS. The detection of pathophysiologically reduced respiratory muscle strength is correlated with weaning failure, longer mechanical ventilation time, and mortality.
View Article and Find Full Text PDFDiaphragmatic pacing for the prevention of sudden unexpected death in epilepsy.
Brain Commun
September 2022
Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, 10 Plum St., New Brunswick, NJ 08901, USA.
Article Synopsis
- Sudden unexpected death in epilepsy is a major problem, and there’s no reliable way to stop it right now.* -
- Researchers think that breathing problems after a seizure are a big reason for this serious issue, and they believe helping patients breathe right after a seizure could save lives.* -
- In a study with mice, those that received help to breathe after a seizure (called diaphragmatic pacing) didn't die, showing it could be an important treatment for people with epilepsy.*
Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury.
Mayo Clin Proc
September 2017
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN. Electronic address:
Spinal cord injury (SCI) is a complex and devastating condition characterized by disruption of descending, ascending, and intrinsic spinal circuitry resulting in chronic neurologic deficits. In addition to limb and trunk sensorimotor deficits, SCI can impair autonomic neurocircuitry such as the motor networks that support respiration and cough. High cervical SCI can cause complete respiratory paralysis, and even lower cervical or thoracic lesions commonly result in partial respiratory impairment.
View Article and Find Full Text PDF[Spinal cord injury (SCI) - Aspects of intensive medical care].
Anasthesiol Intensivmed Notfallmed Schmerzther
September 2014
Gesa Leyk und Sven Hirscheld haben zu gleichen Teilen zum Manuskript beigetragen.
With 2000 new cases/year in Germany spinal cord injury (SCI) is quantitatively less important for intensive care medicine than, e.g., sepsis.
View Article and Find Full Text PDFNoninvasive respiratory management and diaphragm and electrophrenic pacing in neuromuscular disease and spinal cord injury.
Muscle Nerve
February 2013
Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey, B403, 150 Bergen Street, Newark, New Jersey 07103, USA.
The purpose of this monograph is to describe noninvasive management of respiratory muscle weakness/paralysis for patients with neuromuscular disease (NMD) and spinal cord injury (SCI). Noninvasive ventilation (NIV) assists and supports inspiratory muscles, whereas mechanically assisted coughing (MAC) simulates an effective cough. Long-term outcomes will be reviewed as well as the use of NIV, MAC, and electrophrenic pacing (EPP) and diaphragm pacing (DP) to facilitate extubation and decannulation.
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