AI Article Synopsis
- Antimicrobial-resistant strains of Enterobacteriaceae present a significant global health issue, particularly in Vietnam.
- Researchers studied both hospitalized patients and healthy individuals in Ho Chi Minh City to identify sources of antimicrobial resistance.
- They found high levels of resistance to drugs like gentamicin and quinolones, indicating that non-pathogenic intestinal bacteria play a key role in spreading resistance genes.
Article Abstract
Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884939 | PMC |
| http://dx.doi.org/10.1099/jmm.0.010033-0 | DOI Listing |
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