A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case-control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPD GWA study, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ajmg.b.31023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knowledge and Skills of Midwives Regarding Perinatal Mental Health and Their Needs for Further Education.
Cureus
December 2024
Department of Midwifery, University of West Attica, Athens, GRC.
Introduction The literature highlights the crucial role of midwives in assessing and managing perinatal mental health and in providing information to women about related issues. However, research also indicates significant gaps in midwives' knowledge and skills needed to fulfill this role. Data suggest that while midwives are interested in providing mental health support, they lack the confidence, knowledge, and training to do so effectively.
View Article and Find Full Text PDFAssessing the Fear of Covid-19 in Psychiatric Patients: Results from an Italian Multicentric Study.
Clin Neuropsychiatry
December 2024
IRCSS San Gerardo, Monza, Italy.
Objective: Even though the COVID-19 emergency has concluded, its consequences are still relevant. Recent evidence suggests that a significant proportion of individuals experience persistent symptoms long after the initial infection has resolved, classified as "Long COVID" condition. Fear of COVID-19 increases anxiety and stress levels in healthy individuals and exacerbates the symptoms of those with pre-existing psychiatric disorders; therefore understanding the impact of the pandemic on psychiatric disorders remains of utmost importance.
View Article and Find Full Text PDFCare coordination for people living with serious mental illness: understanding the caregiver's perspective.
Front Health Serv
January 2025
Canadian Institute for Advancements in Mental Health, Toronto, ON, Canada.
Introduction: Family caregivers of people living with serious mental illness such as bipolar disorder, psychosis and schizophrenia, are continuously burdened with caregiving, following the complexities of navigating the mental health system for their loved ones. The aim of the study was to understand the perspectives of caregivers about care coordination for people living with serious mental illness, highlighting the current landscape and new directions across Canada.
Methods: In this co-designed participatory qualitative research, caregivers of people living with serious mental illness, and service providers were engaged and purposively sampled across Canada.
Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades.
Front Psychiatry
January 2025
Servicio de Psiquiatría y Salud Mental, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research (IdiPAZ), Universidad Autónoma de Madrid, Madrid, Spain.
In this review, it is evaluated the progress in the application of stem cell therapy to ameliorate the symptoms of bipolar disorder, major depression, schizophrenia, and autism. These disorders are highly prevalent in clinical medicine and are responsible for high levels of psychosocial disability among patients. All of them share common biomedical features, such as complex and variable genetic substrates, significant susceptibility to environmental changes, and insufficient knowledge of their pathogenesis.
View Article and Find Full Text PDFPoor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders.
Front Psychiatry
January 2025
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United States.
Background: Psychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!