Objective: To explore the role of the interaction between beta2-adrenergic receptor (beta2-AR) gene Arg16Gly polymorphism and occupational mental stress in EH.
Methods: Using 1:1 case-control study, we select 95 couple people as the study objects from the high-exposure occupational stress males who work on the train. Measuring occupational stress, stress reaction,anxiety, type A behavior and other occupational mental stress by using proper questionnaire, and applying PCR-RFLP technology to detect adrenergic receptor (beta2-AR) Arg16Gly Polymorphism. Using likelihood ratio test to judge whether it exist the interaction between the potencies and fits the multiplicative model: OR = OR11/(OR01 x OR10).
Results: The distribution of Arg/Arg, Arg/Gly, Gly/Gly in essential hypertension cases and controls are significant difference (P < 0.05), Gly/Gly had a increased risk of hypertension 2.759 (95% CI: 1.200-6.347) compared to Arg/Arg upon controling BMI and other factors. The interaction among Arg16Gly(A/G + G/G) gene.occupational stress reaction and anxiety is fit the multiplicative model. The results showed that when Arg16Gly(A/G + G/G) genotype interact with strain, the risk of EH will add to 12.797 (95% CI: 3.379-48.461). When it interact with anxiety, the risk of EH will add to 40.862 (95% CI: 1.403-119.057).
Conclusion: Arg16Gly polymorphism of beta2-AR might be the crucial risk factor for EH among high-exposure occupational stress males. Individual who has genotype Gly/Gly, while exposure of strain and T-Anxiety is much easier to get EH.
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