Objective: The enantiomer profiling of methamphetamine is can be utilized for regulation of the precursors, investigatin of the drug case.
Methods: In the present study, we investigated on the enantiomer of 114 crystalline methamphetamine samples seized in Beijing, Tianjin, Shijiazhuang and Chengdu. The methamphetamine samples were derivatized with (S)-(+)-a-methoxya-(trifluoromethyl)phenylacetyl chloride ((S)-(+)-MTPACl), and the derivatives were analyzed by GC-MS in selected ion monitoring (SIM) mode.
Results: Most of the seizures were pure S (+)-enantiomer (90.4%), but 3.5% (4 of 114 samples) contained R(-)-enantiomer above 1%.
Conclusion: This indicates that the majority of samples were prepared from either (1R, 2S)-(-)-ephedrine or (1S, 2S)-(+)-pseudoephedrine. At the same time, there were methamphetamine drugs synthesized from (1S, 2R)-(-)-ephedrine or (1R, 2R)-(+)-pseudoephedrine.
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