Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light.

Opt Express

Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute, University of California - Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA.

Published: August 2009

We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850818PMC
http://dx.doi.org/10.1364/oe.17.014780DOI Listing

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