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Comparison of Pediatric- and Adult-Onset Mycosis Fungoides Patients in Terms of Clinical Features and Prognosis in a Large Series.
J Cutan Med Surg
December 2024
Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Background: Studies comparing the clinical and prognostic differences between pediatric- and adult-onset mycosis fungoides (MF) are limited.
Objectives: To determine the impact of childhood-onset MF on clinical features and disease course in a large series.
Methods: Consecutive MF patients seen in a single centre between 2007 and 2021 were categorized into 3 groups: (i) MF patients diagnosed in the pediatric ages (≤18 years) (pediatric group), (ii) MF patients with disease onset in the pediatric period and diagnosis in adulthood (lately diagnosed pediatric-onset group), and (iii) MF patients with disease onset in the adulthood period (>18 years) (adult-onset group).
Folliculotropic and syringotropic mycosis fungoides mimicking basal cell carcinoma.
Dermatol Online J
August 2024
Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Mycosis fungoides (MF) is characterized by a clonal proliferation of skin-homing mature T cells with special predilection for involving the epidermis. Folliculotropic and syringotropic MF typically present with erythematous papules, patches, and plaques, with punctate accentuation that is folliculocentric in the former. We report a 67-year-old woman, with an extensive history of allergic contact dermatitis, who was referred to the Mohs surgery clinic with a large pink plaque extending from the nasal bridge to the right upper medial cheek concerning for basal cell carcinoma.
View Article and Find Full Text PDFUnilesional folliculotropic mycosis fungoides associated with follicular mucinosis in children: 2 cases and literature review.
Ann Dermatol Venereol
December 2024
Department of Dermatology, Saint-Vincent-de-Paul Hospital, Lille Catholic University, Lille, France.
A Case Report of Folliculotropic Mycosis Fungoides: Diagnostic Criteria and Treatment Strategy.
Cureus
October 2024
Department of Dermatology, Scientific/Research National Center of Dermatology and Venereology "Kanveni", Tbilisi, GEO.
Folliculotropic mycosis fungoides (F-MF) is considered a unique variant of mycosis fungoides (MF), which is a form of cutaneous T-cell lymphomas (CTCLs). F-MF can appear in various forms, including patches, papules, plaques, nodules, and tumors. It often affects the face and extremities, with some cases involving the eyebrows.
View Article and Find Full Text PDFNanopore Sequencing for T-Cell Receptor Rearrangement Analysis in Cutaneous T-Cell Lymphoma.
Cancers (Basel)
November 2024
Department of Dermatology, Johannes Wesling Medical Centre, University Hospitals of the Ruhr-University of Bochum (UKRUB), University of Bochum, 32429 Minden, Germany.
Analysis of T-cell receptor (TCR) clonality is a major diagnostic tool for lymphomas, particularly for cutaneous T-cell lymphomas (CTCL) like Mycosis fungoides and Sézary syndrome. However, a fast and cost-effective workflow is needed to enable widespread use of this method. : We established a procedure for TCR rearrangement analysis via Oxford Nanopore Technology (ONT) sequencing.
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