The drawbacks associated with antibiotic-based treatment of infectious diseases including an increase in multidrug-resistant strains and adverse reactions have lead to the search of antimicrobial peptide elicitors (APE), harmless substances that boost an overexpression of innate immunity genes. Knowledge on innate immunity activation pathways and their interactions with adaptive immunity would lead to more effective, faster and safer APE-based treatments to battle infections which still are a common public health problem worldwide.
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